Enhanced Sliding Mode Wheel Slip Controller for Heavy Goods Vehicles

This paper introduces an improved version of a sliding mode slip controller for pneumatic brake system ofheavy goods vehicles, HGVs. Using the Fast Actuating Brake Valve, FABV, allows to adopt advance control approaches forwheel-slip controllers which provide features such as fast dynamic response, stability and robustness. In this paper, the slidingmode algorithm which was developed for the speed dependent wheel slip control using the FABV hardware is analysed andimproved. The asymptotic convergence properties of the control algorithm are proven using Lyapunov stability theory and therobustness of the method is investigate

Velocity Planning for a Racing Driver Model

There is limited information found in literature concerning simulation of limit handling capability of a vehicle model using a driver model. Determining the limit handling capabilities can be a valuable tool for development and analysis of vehicle designs and using a driver model is a convenient way of achieving this . This work presents two different strategies to a driver models that uses the lane for lateral position and limited a priori information about the track in the form of pre-view about curvature ahead of the car. These driver models results in longitudinal velocity planners that uses one single and one multi preview of the reference path. Both strategies have been implemented in the Vehicle Dynamics Library from Modelon using the Modellica language and simulated to illustrate their performance

Velocity Planning for a Racing Driver Model

There is limited information found in literature concerning simulation of limit handling capability of a vehicle model using a driver model. Determining the limit handling capabilities can be a valuable tool for development and analysis of vehicle designs and using a driver model is a convenient way of achieving this . This work presents two different strategies to a driver models that uses the lane for lateral position and limited a priori information about the track in the form of pre-view about curvature ahead of the car. These driver models results in longitudinal velocity planners that uses one single and one multi preview of the reference path. Both strategies have been implemented in the Vehicle Dynamics Library from Modelon using the Modellica language and simulated to illustrate their performance

Inhibition of the Transforming Growth Factor β (TGFβ) Pathway by Interleukin-1β Is Mediated through TGFβ-activated Kinase 1 Phosphorylation of SMAD3

Transforming growth factor β is the prototype of a large family of secreted factors that regulate multiple biological processes. In the immune system, TGFβ acts as an anti-inflammatory and immunosuppressive molecule, whereas the cytokine interleukin (IL)-1β is a crucial mediator of inflammatory responses and induces proinflammatory genes and acute phase proteins. Here, we present evidence for the existence of a direct inhibitory interaction between the IL-1β and TGFβ signaling cascades that is not dependent on IL-1β–induced SMAD7 expression. IL-1β and its downstream mediator TAK1 inhibit SMAD3-mediated TGFβ target gene activation, whereas SMAD3 nuclear translocation and DNA binding in response to TGFβ are not affected. IL-1β transiently induces association between TAK1 and the MAD homology 2 domain of SMAD3, resulting in SMAD3 phosphorylation. Furthermore, IL-1β alleviates the inhibitory effect of TGFβ on in vitro hematopoietic myeloid colony formation. In conclusion, our data provide evidence for the existence of a direct inhibitory effect of the IL-1β-TAK1 pathway on SMAD3-mediated TGFβ signaling, resulting in reduced TGFβ target gene activation and restored proliferation of hematopoietic progenitors